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Previous gene FasterDB identifier: 11454 - OPTN (FIP2, GLC1E, HIP7, HYPL, NRP, TFIIIA-INTP) optineurin Next gene
Gene Close
Symbol OPTN
Synonyms FIP2, GLC1E, HIP7, HYPL, NRP, TFIIIA-INTP
Description optineurin
EnsEMBL link ENSG00000123240
Chromosome 10 - forward strand
Chromosomal location
(UCSC link)		 13141449 - 13180276 (38828bp)
Sequence sequence
Associated transcripts AK055403 NM_001008211 NM_001008213 NM_021980 NM_001008212 AK316171 AK303715 BC032762 BC013876 CR597026 CR603260 CR601600 AF061034 AF420371 AF420372 AF420373 AK122746 AF049614
Alternative 3' splice site (acceptor) Close
 Identifier   Position   Distance (bp)   Transcript 
ASS1 6 94 AK055403
NM_001008211
NM_001008213
NM_021980
NM_001008212
BC032762
BC013876
CR597026
CR603260
CR601600
AF061034
AF420371
AF420372
AF420373
ASS2 9 18 BC032762
CR603260
ASS3 5 15 AK055403
NM_001008213
NM_021980
NM_001008212
AK316171
AK303715
BC032762
BC013876
CR597026
CR603260
CR601600
AF420372
AF420373
Alternative 5' splice sites (donor) Close
 Identifier   Position   Distance (bp)   Transcript 
ASS1 4 -4 NM_001008211
NM_001008213
BC032762
AF420371
Intron retentions Close
 Identifier   Position   Transcript 
IR1 12 AK122746
Exon deletions Close
 Identifier   Position   Transcript 
No data
Transcription start sites Close
 Identifier   Position   Gene coordinates   Chromosomal coordinates   Transcript 
P1 1 1 13141449 AK055403
P2 2 634 13142082 NM_001008211
NM_001008213
NM_021980
NM_001008212
P3 2 688 13142136 AK316171
P4 2 710 13142158 AK303715
P5 11 23918 13165366 AK122746
Protein prediction Close
 Transcript name   Sequence 
AK055403 sequence
NM_001008211 sequence
NM_001008213 sequence
NM_021980 sequence
NM_001008212 sequence
AK316171 sequence
AK303715 sequence
BC032762 sequence
BC013876 sequence
CR597026 sequence
CR603260 sequence
CR601600 sequence
AF061034 sequence
AF420371 sequence
AF420372 sequence
AF420373 sequence
AK122746 sequence
AF049614 sequence
Polyadenylation Close
 Identifier   Position   Gene coordinates of cleavage site   Chromosomal coordinates of cleavage site   Pattern   PolyA tail   Accession number   Type 
PA1 17 37475 13178923 no AK055403 Full_length
PA2 17 37676 13179124 no AK316171 Full_length
PA3 17 37676 13179124 no AK303715 Full_length
PA4 17 38828 13180276 no NM_001008211 Cdna
PA5 17 38828 13180276 no NM_001008213 Cdna
PA6 17 38828 13180276 no NM_021980 Cdna
PA7 17 38828 13180276 no NM_001008212 Cdna
PA8 17 40857 13182305 AATAAA yes AI635684 3prime_est

More polyadenylation sites ...

Exon skipping Close
 Identifier   Position   Transcript 
ES1 2 AK055403
ES2 3 NM_021980
AK316171
AK303715
BC013876
CR597026
CR603260
CR601600
AF420372
ES3 4 AK055403
NM_021980
NM_001008212
AK316171
AK303715
BC013876
CR597026
CR603260
CR601600
AF420372
AF420373
Splice site strength Close
 Identifier   Site   Exon   Strength   Alternative   Sequence 
S1 5' (donor) 1 5.37 no AGGgtgggt
S2 5' (donor) 2 9.6 no CAGgtgagc
S3 3' (acceptor) 2 -14.76 no cggggcccgggaaattccccGGC
S4 5' (donor) 3 5.26 no ATAgtaagc
S5 3' (acceptor) 3 6.27 no taactttgttgttttacaagGTG
S6 5' (donor) 4 -4.77 no TAAgtatta
S7 3' (acceptor) 4 7.86 no ataccttttttgtttaaaagGAA
S8 5' (donor) 4 8.57 yes GGAgtaagt
S9 5' (donor) 5 9.6 no AAGgtgagc
S10 3' (acceptor) 5 8.29 no gacagctctattttcaacagGTG
S11 3' (acceptor) 5 5.92 yes aacaggtgacttttccacagGAA
S12 5' (donor) 6 8.7 no GAGgtgagc
S13 3' (acceptor) 6 7.07 no catggcatctttcaattcagAGC
S14 3' (acceptor) 6 7.48 yes tcactctgaacctcctgcagAAG
S15 5' (donor) 7 7.39 no GCTgtgagt
S16 3' (acceptor) 7 11.21 no ttactccttgtcatctccagGAC
S17 5' (donor) 8 7.26 no CACgtatgt
S18 3' (acceptor) 8 8.92 no ttgcatttctgttttcacagGAA
S19 5' (donor) 9 9.11 no AAGgtatga
S20 3' (acceptor) 9 6.66 no ttaacctttatactgaacagGGC
S21 3' (acceptor) 9 2.49 yes agggcattgtctaaatatagGAG
S22 5' (donor) 10 7.94 no ACTgtgagt
S23 3' (acceptor) 10 9.44 no tatcttctgtgattttccagAGT
S24 5' (donor) 11 6.91 no AAAgtaaga
S25 3' (acceptor) 11 6.03 no tgggatttcccgtatgatagGTT
S26 5' (donor) 12 8.4 no AAAgtgagt
S27 3' (acceptor) 12 6.14 no gaaatcttgacctttcttagGTG
S28 5' (donor) 13 6.35 no GAGgtattc
S29 3' (acceptor) 13 9.31 no tttaatatcttttttaatagGTC
S30 5' (donor) 14 10.07 no CAGgtgagg
S31 3' (acceptor) 14 8.62 no aataaatgtttctttttcagTCA
S32 5' (donor) 15 11.08 no CAGgtaagg
S33 3' (acceptor) 15 11.3 no atctttttttcctctaacagATG
S34 5' (donor) 16 10.03 no GAGgtgagt
S35 3' (acceptor) 16 9.08 no gttgcttttcgtcctggcagGCA
S36 3' (acceptor) 17 5.59 no attatcatacttattcccagGAG
Conserved exons Close
 Gene identifier mouse   Position human  Position mouse 
9602 5 2
9602 6 3
9602 7 4
9602 9 6
9602 10 8
9602 11 9
9602 12 10
9602 13 11
9602 14 12
9602 15 13
9602 16 14
9602 17 15
Report Close
 Exon   Number of supporting transcripts 
 Transcription initiation & first exon(s) 
1 1
2 3
11 1
 Transcription termination & last exon(s) 
17 8
 Exon skipping 
2 1
3 8
4 11
 Alternative 3' splice sites 
5 1
6 1
9 1
 Alternative 5' splice sites 
4 1
 Intron retentions 
12 1
Splicing factors Close
 Splicing factor   Exon array   CLIP data   Exon position 
CELF1 (CUG-BP)
 
DAZAP1
 
ELAVL1 (HuR) Yes Yes
 
ESRP1/2 (ESRP) Yes
 
FUS Yes
 
HNRNPA1 Yes
 
HNRNPA2B1 Yes
 
HNRNPAB
 
HNRNPC Yes
 
HNRNPF/HNRNPH1 Yes Yes
 
HNRNPL Yes
 
HNRNPL_2
 
HNRNPM Yes
 
HNRNPU Yes
 
MBNL
 
NOVA1
 
PTBP1/2 (PTB) Yes Yes
 
QKI
 
RBFOX2 (FOX2) Yes
 
RBM4 Yes
 
SFRS3 (SRP20)
 
SFRS6 (SRP55)
 
SFRS7 (9G8)
 
SRSF1 (SF2ASF)
 
SRSF2 (SC35)
 
SRSF5 (SRP40)
 
TDP43
 
TIA1/TIAL1 Yes
 
TRA2A
 
TRA2B
 
YBX1 (YB1)
 
Expression Close
 Exon position   Tissues   Cell lines   Cancer cell lines 
1 Expression Expression Expression
2 Expression Expression Expression
3 Expression Expression Expression
4 Expression Expression Expression
5 Expression Expression Expression
6 Expression Expression Expression
7 Expression Expression Expression
8 Expression Expression Expression
9 Expression Expression Expression
10 Expression Expression Expression
11 Expression Expression Expression
12 Expression Expression Expression
13 Expression Expression Expression
14 Expression Expression Expression
15 Expression Expression Expression
16 Expression Expression Expression
17 Expression Expression Expression
Exon-Intron Close
 Position   Type   Gene coordinates   Chromosomal coordinates   Length   Sequence   Features 
1 Exon 1 - 510 13141449 - 13141958 510 sequence download
1 Intron 511 - 633 13141959 - 13142081 123 sequence -
2 Exon 634 - 854 13142082 - 13142302 221 sequence download
2 Intron 855 - 8689 13142303 - 13150137 7835 sequence -
3 Exon 8690 - 8841 13150138 - 13150289 152 sequence download
3 Intron 8842 - 9513 13150290 - 13150961 672 sequence -
4 Exon 9514 - 9571 13150962 - 13151019 58 sequence download
4 Intron 9572 - 9648 13151020 - 13151096 77 sequence -
5 Exon 9649 - 9840 13151097 - 13151288 192 sequence download
5 Intron 9841 - 10731 13151289 - 13152179 891 sequence -
6 Exon 10732 - 11028 13152180 - 13152476 297 sequence download
6 Intron 11029 - 13004 13152477 - 13154452 1976 sequence -
7 Exon 13005 - 13187 13154453 - 13154635 183 sequence download
7 Intron 13188 - 16818 13154636 - 13158266 3631 sequence -
8 Exon 16819 - 16892 13158267 - 13158340 74 sequence download
8 Intron 16893 - 19439 13158341 - 13160887 2547 sequence -
9 Exon 19440 - 19592 13160888 - 13161040 153 sequence download
9 Intron 19593 - 22936 13161041 - 13164384 3344 sequence -
10 Exon 22937 - 23039 13164385 - 13164487 103 sequence download
10 Intron 23040 - 24546 13164488 - 13165994 1507 sequence -
11 Exon 24547 - 24662 13165995 - 13166110 116 sequence download
11 Intron 24663 - 25969 13166111 - 13167417 1307 sequence -
12 Exon 25970 - 26119 13167418 - 13167567 150 sequence download
12 Intron 26120 - 26497 13167568 - 13167945 378 sequence -
13 Exon 26498 - 26591 13167946 - 13168039 94 sequence download
13 Intron 26592 - 28296 13168040 - 13169744 1705 sequence -
14 Exon 28297 - 28455 13169745 - 13169903 159 sequence download
14 Intron 28456 - 32618 13169904 - 13174066 4163 sequence -
15 Exon 32619 - 32749 13174067 - 13174197 131 sequence download
15 Intron 32750 - 34053 13174198 - 13175501 1304 sequence -
16 Exon 34054 - 34133 13175502 - 13175581 80 sequence download
16 Intron 34134 - 37296 13175582 - 13178744 3163 sequence -
17 Exon 37297 - 38828 13178745 - 13180276 1532 sequence download
Close  5' untranslated regions 
 UTR 1   UTR 2   UTR 3   UTR 4   UTR 5   UTR 6   UTR 7   UTR 8 
 Supporting GenBank
accession identifers 		 AK055403
 NM_001008211
BC032762
AF061034
AF420371
AF420373
 NM_001008213
 NM_001008212
 NM_021980
 AK316171
BC013876
CR603260
CR601600
AF420372
 AK303715
 AK122746
 Length  673 453 438 384 232 443 421 1295
 Number of ATGs in frame  4 1 1 1 1 1 1 7
 Total number of ATGs  10 5 5 3 1 5 5 23
 Number of GTGs in frame  8 6 6 6 1 3 3 7
 Total number of GTGs  20 16 16 15 8 15 15 20
 Number of CTGs in frame  1 2 2 1 0 2 2 7
 Total number of CTGs  8 8 7 6 1 6 6 13
 Number of micro ORFs in frame  2 1 1 1 1 0 0 2
 Total number of micro ORFs  5 4 4 3 1 2 2 12
 GC percentage  53 61 62 65 74 62 61 38
 Number of pyrimidine tracks  5 2 2 2 1 3 3 8
Close 3' untranslated regions 
 UTR 1 
 Supporting GenBank
accession identifers 		 NM_001008211
NM_001008213
NM_021980
NM_001008212
BC013876
BC032762
AK316171
AK303715
AK055403
AF061034
AK122746
AF420371
AF420372
AF420373
CR601600
 Length  1410
 Number of ATGs in frame  14
 Total number of ATGs  28
 Number of GTGs in frame  6
 Total number of GTGs  25
 Number of CTGs in frame  10
 Total number of CTGs  24
 GC percentage  39
 Number of pyrimidine tracks  9
miRNAs Close
 Identifier    Name    Gene coordinates   Chromosomal coordinates   Prediction algorithm 
Group 1
M1 hsa-miR-432 37469 - 37475 13178917 - 13178923 pita
Group 2
M1 hsa-miR-570 37496 - 37502 13178944 - 13178950 pita
Group 3
M1 hsa-miR-361-5p 37944 - 37965 13179392 - 13179413 miranda
M2 hsa-miR-324-5p 38089 - 38110 13179537 - 13179558 miranda
M3 hsa-miR-9 38235 - 38257 13179683 - 13179705 miranda
M4 hsa-miR-9 38250 - 38257 13179698 - 13179705 targetscan
M5 hsa-miR-449a 38432 - 38455 13179880 - 13179903 miranda
M6 hsa-miR-449b 38432 - 38455 13179880 - 13179903 miranda
M7 hsa-miR-590-3p 38500 - 38520 13179948 - 13179968 miranda
M8 hsa-miR-590-3p 38512 - 38519 13179960 - 13179967 pita
M9 hsa-miR-182 38738 - 38761 13180186 - 13180209 miranda
M10 hsa-miR-199a-5p 38755 - 38777 13180203 - 13180225 miranda
M11 hsa-miR-199b-5p 38755 - 38777 13180203 - 13180225 miranda
Protein features Close
 Category   Feature identifier   Feature name   Exons   Start on gene   End on gene 
Binding EXONT:001885 Protein binding 5,6,7 9675 13016
Binding EXONT:001885 Protein binding 7,8 13095 16824
Binding EXONT:001885 Protein binding 8 16843 16845
Binding EXONT:001885 Protein binding 9,10,11,12,13,14,15,16,17 19441 37415
Binding EXONT:004898 Identical protein binding 12,13,14,15,16,17 25971 37415
Localization EXONT:000067 Nuclear_export_signal 14,15 28429 32639
Localization EXONT:000067 Nuclear_export_signal 17 37362 37406
Structure EXONT:000074 Intrinsically_unstructured_polypeptide_region 5 9675 9809
Structure EXONT:000035 Coiled_coil 5,6,7 9786 13145
Structure EXONT:000074 Intrinsically_unstructured_polypeptide_region 6,7 10945 13073
Structure EXONT:000074 Intrinsically_unstructured_polypeptide_region 7,8,9,9 13134 19491
Structure EXONT:000051 Beta_strand 7 13167 13175
Structure EXONT:000035 Coiled_coil 9,10,11,12,13,14,15 19528 32741
Structure EXONT:000074 Intrinsically_unstructured_polypeptide_region 9,10,11 19591 24564
Structure EXONT:000074 Intrinsically_unstructured_polypeptide_region 12 25983 26012
Structure EXONT:000074 Intrinsically_unstructured_polypeptide_region 14 28399 28428
Structure EXONT:000074 Intrinsically_unstructured_polypeptide_region 15,16 32742 34117
Structure EXONT:000022 Polypeptide_turn_motif 17 37350 37364
Structure EXONT:000037 Peptide_helix 17 37380 37406
PTM EXONT:000161 O-phospho-L-serine 5 9717 9719
PTM EXONT:000161 O-phospho-L-serine 5 9723 9725
PTM EXONT:000162 O-phospho-L-threonine 5 9780 9782
PTM EXONT:000161 O-phospho-L-serine 7 13143 13148
PTM EXONT:000161 O-phospho-L-serine 7 13152 13157
PTM EXONT:000161 O-phospho-L-serine 7 13164 13166
PTM EXONT:000161 O-phospho-L-serine 8 16858 16860
PTM EXONT:000162 O-phospho-L-threonine 8 16876 16878
PTM EXONT:000161 O-phospho-L-serine 8 16882 16884
PTM EXONT:000162 O-phospho-L-threonine 8,9 16891 19440
PTM EXONT:000180 N-acetylated L-lysine 11,12 24661 25970
PTM EXONT:000192 N6-acetyl-L-lysine 11,12 24661 25970
PTM EXONT:000161 O-phospho-L-serine 12 25995 25997
PTM EXONT:000164 O4'-phospho-L-tyrosine 12 26037 26039
PTM EXONT:000797 Ubiquitinylated lysine 14 28396 28398
PTM EXONT:000180 N-acetylated L-lysine 14 28411 28413
PTM EXONT:000192 N6-acetyl-L-lysine 14 28411 28413
PTM EXONT:000161 O-phospho-L-serine 15 32634 32636
PTM EXONT:000797 Ubiquitinylated lysine 15 32682 32684
PTM EXONT:000797 Ubiquitinylated lysine 15 32718 32720
PTM EXONT:000161 O-phospho-L-serine 16 34058 34060
PTM EXONT:000161 O-phospho-L-serine 16 34076 34078
PTM EXONT:000162 O-phospho-L-threonine 16 34094 34096
PTM EXONT:000161 O-phospho-L-serine 16 34097 34099
PTM EXONT:000161 O-phospho-L-serine 16 34103 34105
PTM EXONT:000164 O4'-phospho-L-tyrosine 16 34118 34120
Unclassified EXONT:009211 NF-kappa-B essential modulator NEMO, N-terminal 5,6,6 9786 10971
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Exon 1Exon 2Exon 3Exon 4Exon 5Exon 6Exon 7Exon 8Exon 9Exon 10Exon 11Exon 12Exon 13Exon 14Exon 15Exon 16Exon 1Exon 2Exon 3Exon 4Exon 5Exon 6Exon 7Exon 8Exon 9Exon 10Exon 11Exon 12Exon 13Exon 14Exon 15Exon 16Exon 17Extended region