Download PDF   |   Home   |   Legend
Previous gene FasterDB identifier: 16967 - ERN1 (IRE1, IRE1P) endoplasmic reticulum to nucleus signaling 1 Next gene
Gene Close
Symbol ERN1
Synonyms IRE1, IRE1P
Description endoplasmic reticulum to nucleus signaling 1
EnsEMBL link ENSG00000178607
Chromosome 17 - reverse strand
Chromosomal location
(UCSC link)		 62120353 - 62207528 (87176bp)
Sequence sequence
Associated transcripts AK292403 NM_001433 AB209869 AF059198 BC130405 BC130407
Alternative 3' splice site (acceptor) Close
 Identifier   Position   Distance (bp)   Transcript 
Alternative 5' splice sites (donor) Close
 Identifier   Position   Distance (bp)   Transcript 
Intron retentions Close
 Identifier   Position   Transcript 
Exon deletions Close
 Identifier   Position   Transcript 
No data
Transcription start sites Close
 Identifier   Position   Gene coordinates   Chromosomal coordinates   Transcript 
P1 1 1 62207528 AK292403
Protein prediction Close
 Transcript name   Sequence 
AK292403 sequence
NM_001433 sequence
AB209869 sequence
AF059198 sequence
BC130405 sequence
BC130407 sequence
Polyadenylation Close
 Identifier   Position   Gene coordinates of cleavage site   Chromosomal coordinates of cleavage site   Pattern   PolyA tail   Accession number   Type 
PA1 22 86219 62121310 no AK292403 Full_length
PA2 22 87176 62120353 no AB209869 Cdna

More polyadenylation sites ...

Exon skipping Close
 Identifier   Position   Transcript 
No data
Splice site strength Close
 Identifier   Site   Exon   Strength   Alternative   Sequence 
S1 5' (donor) 1 7.93 no GGGgtgagt
S2 5' (donor) 2 8.83 no AAGgtaatt
S3 3' (acceptor) 2 9.04 no tcttctacatctcgttgcagATT
S4 5' (donor) 3 9.35 no AGAgtaagt
S5 3' (acceptor) 3 9.04 no tttgttgttcttttgcacagATC
S6 5' (donor) 4 11.45 no ACGgtgagt
S7 3' (acceptor) 4 8.43 no atttattatttaatctctagGCC
S8 5' (donor) 5 8.91 no TGGgtaaga
S9 3' (acceptor) 5 8.13 no ctttttttttttttttaaagAAA
S10 5' (donor) 6 10.77 no CAGgtaaga
S11 3' (acceptor) 6 13.92 no gtgtttttgtgtcctttcagGTA
S12 5' (donor) 7 9.49 no ACAgtaagt
S13 3' (acceptor) 7 7.23 no ggctggtctgtgttctttagAAT
S14 5' (donor) 8 9.22 no GACgtgagt
S15 3' (acceptor) 8 5.64 no tgtttatttgatctgtacagAGA
S16 5' (donor) 9 10.36 no GTGgtaagt
S17 3' (acceptor) 9 10.83 no tgtatctgtttttctcctagGCC
S18 5' (donor) 10 9.14 no TAGgtaaga
S19 3' (acceptor) 10 10.39 no tcactgcaccctctccacagCCC
S20 5' (donor) 11 7.97 no GAAgtgagt
S21 3' (acceptor) 11 8.62 no ggttttgtttcctgtcatagGAC
S22 5' (donor) 12 5.75 no CTGgtaaag
S23 3' (acceptor) 12 4.91 no gcaactctctcccatgcaagGTT
S24 5' (donor) 13 8.27 no GAGgtaaag
S25 3' (acceptor) 13 9.17 no atgtgggtttctcttcccagAGC
S26 5' (donor) 14 10.9 no CCGgtgagt
S27 3' (acceptor) 14 10.52 no tttttcctattttgtcccagATG
S28 5' (donor) 15 1.48 no GAGgtggat
S29 3' (acceptor) 15 10.17 no tcccactcctcatcccgcagGGG
S30 5' (donor) 16 8.51 no TCGgtgaga
S31 3' (acceptor) 16 9.16 no tgctgtcatgtcttttgcagTAT
S32 5' (donor) 17 7.21 no CCTgtgagt
S33 3' (acceptor) 17 -1.21 no aatctggagttctctgttagTTC
S34 5' (donor) 18 9.44 no ACGgtgagc
S35 3' (acceptor) 18 10.42 no cgcctcatgtctcttttcagACC
S36 5' (donor) 19 7.1 no CAGgtagag
S37 3' (acceptor) 19 8.64 no cttattttcctcctttatagAAG
S38 5' (donor) 20 4.28 no CAGgtgatc
S39 3' (acceptor) 20 12.07 no tgcccttgtttctctcacagGAC
S40 5' (donor) 21 10.22 no AAGgtaagc
S41 3' (acceptor) 21 9.12 no ttccctcaatgtttttctagACC
S42 3' (acceptor) 22 7.73 no agctttctaactctttgcagAAG
Conserved exons Close
 Gene identifier mouse   Position human  Position mouse 
19030 1 1
19030 2 2
19030 3 3
19030 4 4
19030 5 5
19030 6 6
19030 7 7
19030 8 8
19030 9 9
19030 10 10
19030 11 11
19030 12 12
19030 13 13
19030 14 14
19030 15 15
19030 16 16
19030 17 17
19030 18 18
19030 19 19
19030 20 20
19030 21 21
Report Close
 Exon   Number of supporting transcripts 
 Transcription initiation & first exon(s) 
1 1
 Transcription termination & last exon(s) 
22 2
Splicing factors Close
 Splicing factor   Exon array   CLIP data   Exon position 
CELF1 (CUG-BP)
 
DAZAP1
 
ELAVL1 (HuR) Yes Yes
 
ESRP1/2 (ESRP) Yes
 
FUS Yes
 
HNRNPA1 Yes
 
HNRNPA2B1 Yes
 
HNRNPAB
 
HNRNPC Yes
 
HNRNPF/HNRNPH1 Yes Yes
 
HNRNPL Yes
 
HNRNPL_2
 
HNRNPM Yes
 
HNRNPU Yes
 
MBNL
 
NOVA1
 
PTBP1/2 (PTB) Yes Yes
 
QKI
 
RBFOX2 (FOX2) Yes
 
RBM4 Yes
 
SFRS3 (SRP20)
 
SFRS6 (SRP55)
 
SFRS7 (9G8)
 
SRSF1 (SF2ASF)
 
SRSF2 (SC35)
 
SRSF5 (SRP40)
 
TDP43
 
TIA1/TIAL1 Yes
 
TRA2A
 
TRA2B
 
YBX1 (YB1)
 
Expression Close
 Exon position   Tissues   Cell lines   Cancer cell lines 
1 Expression Expression Expression
2 Expression Expression Expression
3 Expression Expression Expression
4 Expression Expression Expression
5 Expression Expression Expression
6 Expression Expression Expression
7 Expression Expression Expression
8 Expression Expression Expression
9 Expression Expression Expression
10 Expression Expression Expression
11 Expression Expression Expression
12 Expression Expression Expression
13 Expression Expression Expression
14 Expression Expression Expression
15 Expression Expression Expression
16 Expression Expression Expression
17 Expression Expression Expression
18 Expression Expression Expression
19 Expression Expression Expression
20 Expression Expression Expression
21 Expression Expression Expression
22 Expression Expression Expression
Exon-Intron Close
 Position   Type   Gene coordinates   Chromosomal coordinates   Length   Sequence   Features 
1 Exon 1 - 193 62207336-62207528 193 sequence download
1 Intron 194 - 31927 62175602-62207335 31734 sequence -
2 Exon 31928 - 32048 62175481-62175601 121 sequence download
2 Intron 32049 - 49360 62158169-62175480 17312 sequence -
3 Exon 49361 - 49394 62158135-62158168 34 sequence download
3 Intron 49395 - 50434 62157095-62158134 1040 sequence -
4 Exon 50435 - 50507 62157022-62157094 73 sequence download
4 Intron 50508 - 54921 62152608-62157021 4414 sequence -
5 Exon 54922 - 54994 62152535-62152607 73 sequence download
5 Intron 54995 - 58065 62149464-62152534 3071 sequence -
6 Exon 58066 - 58188 62149341-62149463 123 sequence download
6 Intron 58189 - 61877 62145652-62149340 3689 sequence -
7 Exon 61878 - 61979 62145550-62145651 102 sequence download
7 Intron 61980 - 63236 62144293-62145549 1257 sequence -
8 Exon 63237 - 63498 62144031-62144292 262 sequence download
8 Intron 63499 - 64881 62142648-62144030 1383 sequence -
9 Exon 64882 - 64960 62142569-62142647 79 sequence download
9 Intron 64961 - 66017 62141512-62142568 1057 sequence -
10 Exon 66018 - 66183 62141346-62141511 166 sequence download
10 Intron 66184 - 69581 62137948-62141345 3398 sequence -
11 Exon 69582 - 69700 62137829-62137947 119 sequence download
11 Intron 69701 - 72175 62135354-62137828 2475 sequence -
12 Exon 72176 - 72367 62135162-62135353 192 sequence download
12 Intron 72368 - 74220 62133309-62135161 1853 sequence -
13 Exon 74221 - 74494 62133035-62133308 274 sequence download
13 Intron 74495 - 75340 62132189-62133034 846 sequence -
14 Exon 75341 - 75431 62132098-62132188 91 sequence download
14 Intron 75432 - 75729 62131800-62132097 298 sequence -
15 Exon 75730 - 75919 62131610-62131799 190 sequence download
15 Intron 75920 - 76797 62130732-62131609 878 sequence -
16 Exon 76798 - 76897 62130632-62130731 100 sequence download
16 Intron 76898 - 77189 62130340-62130631 292 sequence -
17 Exon 77190 - 77389 62130140-62130339 200 sequence download
17 Intron 77390 - 80966 62126563-62130139 3577 sequence -
18 Exon 80967 - 81114 62126415-62126562 148 sequence download
18 Intron 81115 - 82183 62125346-62126414 1069 sequence -
19 Exon 82184 - 82311 62125218-62125345 128 sequence download
19 Intron 82312 - 84686 62122843-62125217 2375 sequence -
20 Exon 84687 - 84810 62122719-62122842 124 sequence download
20 Intron 84811 - 85241 62122288-62122718 431 sequence -
21 Exon 85242 - 85309 62122220-62122287 68 sequence download
21 Intron 85310 - 85968 62121561-62122219 659 sequence -
22 Exon 85969 - 87176 62120353-62121560 1208 sequence download
Close  5' untranslated regions 
 UTR 1   UTR 2 
 Supporting GenBank
accession identifers 		 AK292403
NM_001433
AB209869
BC130405
BC130407
 AF059198
 Length  139 96
 Number of ATGs in frame  1 0
 Total number of ATGs  1 0
 Number of GTGs in frame  2 0
 Total number of GTGs  5 2
 Number of CTGs in frame  1 0
 Total number of CTGs  1 0
 Number of micro ORFs in frame  1 0
 Total number of micro ORFs  1 0
 GC percentage  76 79
 Number of pyrimidine tracks  1 0
Close 3' untranslated regions 
 UTR 1 
 Supporting GenBank
accession identifers 		 AB209869
NM_001433
AF059198
BC130405
BC130407
AK292403
 Length  995
 Number of ATGs in frame  6
 Total number of ATGs  15
 Number of GTGs in frame  12
 Total number of GTGs  30
 Number of CTGs in frame  9
 Total number of CTGs  28
 GC percentage  59
 Number of pyrimidine tracks  2
miRNAs Close
 Identifier    Name    Gene coordinates   Chromosomal coordinates   Prediction algorithm 
Group 1
M1 hsa-miR-124 86293 - 86300 62121229 - 62121236 targetscan
M2 hsa-miR-506 86293 - 86300 62121229 - 62121236 targetscan
M3 hsa-miR-124 86294 - 86300 62121229 - 62121235 pita
M4 hsa-miR-506 86294 - 86300 62121229 - 62121235 pita
Protein features Close
 Category   Feature identifier   Feature name   Exons   Start on gene   End on gene 
Catalytic EXONT:002406 Protein kinase domain 14,15,16,17,18,19 75379 82278
Catalytic EXONT:002212 Protein kinase-like domain 14,15,16,17,18,19,20 75379 84710
Catalytic EXONT:005262 Serine/threonine-protein kinase, active site 16,17 76894 77224
Catalytic EXONT:005714 KEN domain 19,20,21,22 82285 86136
Binding EXONT:001885 Protein binding 2,3,4,5,6,7,8,9,10,11 31943 69664
Binding EXONT:004898 Identical protein binding 2,3,4,5,6,7,8,9,10,11 31943 69664
Binding EXONT:001885 Protein binding 12,13,14,15,16,17,18,19,20,21,22 72362 86178
Binding EXONT:004898 Identical protein binding 13,14,15,16,17,18,19,20,21,22 74461 86178
Binding EXONT:002406 Protein kinase domain 14,15,16,17,18,19 75379 82278
Binding EXONT:000062 Nucleotide_binding_site 14 75397 75423
Binding EXONT:004629 PUG domain 21,22 85271 86103
Localization EXONT:000069 ER_retention_signal 1 140 154
Localization EXONT:000019 Signal_peptide 1 140 193
Localization EXONT:000071 Transmembrane_helix 1,2 158 31960
Localization EXONT:000067 Nuclear_export_signal 8 63359 63400
Localization EXONT:000071 Transmembrane_helix 12 72299 72361
Localization EXONT:000065 Endosomal_localization_signal 17,18 77384 80972
Localization EXONT:000066 Lysosomal_localization_signal 17,18 77384 80972
Localization EXONT:000064 Nuclear_localization_signal 22 86104 86127
Structure EXONT:000071 Transmembrane_helix 1,2 158 31960
Structure EXONT:008327 Pyrrolo-quinoline quinone beta-propeller repeat 2 31949 32044
Structure EXONT:000051 Beta_strand 2 31967 31984
Structure EXONT:000051 Beta_strand 2 31991 32011
Structure EXONT:000022 Polypeptide_turn_motif 2 32012 32020
Structure EXONT:000051 Beta_strand 2 32027 32044
Structure EXONT:000051 Beta_strand 4 50442 50450
Structure EXONT:000022 Polypeptide_turn_motif 4 50454 50462
Structure EXONT:000051 Beta_strand 4 50469 50477
Structure EXONT:000051 Beta_strand 4,5 50502 54924
Structure EXONT:000037 Peptide_helix 5 54937 54951
Structure EXONT:008327 Pyrrolo-quinoline quinone beta-propeller repeat 5,6 54961 58130
Structure EXONT:000051 Beta_strand 6 58068 58094
Structure EXONT:008327 Pyrrolo-quinoline quinone beta-propeller repeat 6,7 58146 61933
Structure EXONT:000051 Beta_strand 6,7 58170 61891
Structure EXONT:000051 Beta_strand 7 61901 61915
Structure EXONT:000051 Beta_strand 7 61925 61945
Structure EXONT:008327 Pyrrolo-quinoline quinone beta-propeller repeat 7,8 61964 63319
Structure EXONT:000051 Beta_strand 8 63245 63259
Structure EXONT:000051 Beta_strand 8 63269 63283
Structure EXONT:000022 Polypeptide_turn_motif 8 63287 63295
Structure EXONT:000051 Beta_strand 8 63302 63319
Structure EXONT:000051 Beta_strand 8 63332 63349
Structure EXONT:000051 Beta_strand 8 63368 63376
Structure EXONT:000051 Beta_strand 8 63383 63394
Structure EXONT:000037 Peptide_helix 8 63395 63448
Structure EXONT:000037 Peptide_helix 8 63473 63493
Structure EXONT:008327 Pyrrolo-quinoline quinone beta-propeller repeat 8,9,10 63485 66020
Structure EXONT:000051 Beta_strand 8,9 63494 64891
Structure EXONT:000051 Beta_strand 9 64895 64903
Structure EXONT:000051 Beta_strand 9 64928 64939
Structure EXONT:000022 Polypeptide_turn_motif 10 66171 66179
Structure EXONT:000074 Intrinsically_unstructured_polypeptide_region 11 69635 69676
Structure EXONT:000074 Intrinsically_unstructured_polypeptide_region 11,12 69698 72283
Structure EXONT:000071 Transmembrane_helix 12 72299 72361
Structure EXONT:000074 Intrinsically_unstructured_polypeptide_region 13 74233 74280
Structure EXONT:000074 Intrinsically_unstructured_polypeptide_region 13,14 74290 75354
Structure EXONT:000051 Beta_strand 14 75358 75366
Structure EXONT:000051 Beta_strand 14 75373 75405
Structure EXONT:000037 Peptide_helix 14 75409 75417
Structure EXONT:000051 Beta_strand 14,15 75421 75769
Structure EXONT:000022 Polypeptide_turn_motif 15 75773 75781
Structure EXONT:000051 Beta_strand 15 75782 75790
Structure EXONT:000037 Peptide_helix 15 75794 75820
Structure EXONT:000051 Beta_strand 15 75848 75868
Structure EXONT:000051 Beta_strand 15 75875 75895
Structure EXONT:000051 Beta_strand 15 75902 75910
Structure EXONT:000037 Peptide_helix 15,16 75911 76806
Structure EXONT:000051 Beta_strand 16 76807 76815
Structure EXONT:000037 Peptide_helix 16 76837 76887
Structure EXONT:000051 Beta_strand 17 77213 77224
Structure EXONT:000051 Beta_strand 17 77255 77263
Structure EXONT:000051 Beta_strand 17 77276 77284
Structure EXONT:000037 Peptide_helix 17 77354 77362
Structure EXONT:000037 Peptide_helix 18 80973 81017
Structure EXONT:000022 Polypeptide_turn_motif 18 81045 81053
Structure EXONT:000037 Peptide_helix 18 81054 81071
Structure EXONT:000037 Peptide_helix 18,19 81111 82218
Structure EXONT:000037 Peptide_helix 19 82231 82239
Structure EXONT:000037 Peptide_helix 19 82249 82263
Structure EXONT:000022 Polypeptide_turn_motif 19 82270 82278
Structure EXONT:000037 Peptide_helix 19,20 82285 84701
Structure EXONT:000037 Peptide_helix 20 84726 84749
Structure EXONT:000022 Polypeptide_turn_motif 20 84759 84770
Structure EXONT:000037 Peptide_helix 20 84777 84785
Structure EXONT:000037 Peptide_helix 20,21 84795 85243
Structure EXONT:000037 Peptide_helix 21,22 85277 85974
Structure EXONT:000022 Polypeptide_turn_motif 22 85975 85986
Structure EXONT:000037 Peptide_helix 22 85993 86013
Structure EXONT:000037 Peptide_helix 22 86026 86049
Structure EXONT:000037 Peptide_helix 22 86065 86100
Structure EXONT:000051 Beta_strand 22 86101 86109
Structure EXONT:000037 Peptide_helix 22 86110 86118
Structure EXONT:000022 Polypeptide_turn_motif 22 86119 86127
PTM EXONT:000162 O-phospho-L-threonine 2 32018 32020
PTM EXONT:000164 O4'-phospho-L-tyrosine 5 54988 54990
PTM EXONT:000162 O-phospho-L-threonine 6 58104 58106
PTM EXONT:000164 O4'-phospho-L-tyrosine 7 61880 61882
PTM EXONT:000164 O4'-phospho-L-tyrosine 7 61895 61897
PTM EXONT:000992 N4-(N-acetylamino)glucosyl-L-asparagine 7 61925 61927
PTM EXONT:000164 O4'-phospho-L-tyrosine 7 61934 61936
PTM EXONT:000162 O-phospho-L-threonine 9 64886 64888
PTM EXONT:000164 O4'-phospho-L-tyrosine 9 64904 64906
PTM EXONT:000180 N-acetylated L-lysine 11 69614 69616
PTM EXONT:000192 N6-acetyl-L-lysine 11 69614 69616
PTM EXONT:000161 O-phospho-L-serine 13 74419 74421
PTM EXONT:000161 O-phospho-L-serine 13 74452 74454
PTM EXONT:000161 O-phospho-L-serine 13 74464 74466
PTM EXONT:000161 O-phospho-L-serine 13 74473 74475
PTM EXONT:000797 Ubiquitinylated lysine 15 75863 75865
PTM EXONT:000161 O-phospho-L-serine 17 77306 77308
PTM EXONT:000161 O-phospho-L-serine 17 77312 77314
PTM EXONT:000162 O-phospho-L-threonine 22 86164 86166
Unclassified EXONT:005921 Quinonprotein alcohol dehydrogenase-like superfamily 2,3,4,5,6,7,8 31937 63331
Unclassified EXONT:010950 Quinonprotein alcohol dehydrogenase-like domain 2,3,4,5,6,7,8 31937 63340
Gene ERN1
Gene ERN1 Gene ERN1
Gene ERN1 Gene ERN1
Gene ERN1 Gene ERN1
Gene ERN1 Gene ERN1
Gene ERN1 Gene ERN1
Gene ERN1 Gene ERN1
Gene ERN1 Gene ERN1
Gene ERN1 Gene ERN1

Please wait while loading ...

Loading

Exon 1Exon 2Exon 3Exon 4Exon 5Exon 6Exon 7Exon 8Exon 9Exon 10Exon 11Exon 12Exon 13Exon 14Exon 15Exon 16Exon 17Exon 18Exon 19Exon 20Exon 21Exon 1Exon 2Exon 3Exon 4Exon 5Exon 6Exon 7Exon 8Exon 9Exon 10Exon 11Exon 12Exon 13Exon 14Exon 15Exon 16Exon 17Exon 18Exon 19Exon 20Exon 21Exon 22Extended region