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Previous gene FasterDB identifier: 17439 - SMURF2 (ENSG00000108854) SMAD specific E3 ubiquitin protein ligase 2 Next gene
Gene Close
Symbol SMURF2
Synonyms ENSG00000108854
Description SMAD specific E3 ubiquitin protein ligase 2
EnsEMBL link ENSG00000108854
Chromosome 17 - reverse strand
Chromosomal location
(UCSC link)
62538418 - 62658386 (119969bp)
Sequence sequence
Associated transcripts NM_022739 CR936721 AY014180 BC051283 BC093876 BC111945 AF301463 AF310676 BC009527
Alternative 3' splice site (acceptor) Close
 Identifier   Position   Distance (bp)   Transcript 
Alternative 5' splice sites (donor) Close
 Identifier   Position   Distance (bp)   Transcript 
Intron retentions Close
 Identifier   Position   Transcript 
Exon deletions Close
 Identifier   Position   Transcript 
ED1 1 CR936721
Transcription start sites Close
 Identifier   Position   Gene coordinates   Chromosomal coordinates   Transcript 
P1 1 1 62658386 NM_022739
Protein prediction Close
 Transcript name   Sequence 
NM_022739 sequence
CR936721 sequence
AY014180 sequence
BC051283 sequence
BC093876 sequence
BC111945 sequence
AF301463 sequence
AF310676 sequence
BC009527 sequence
Polyadenylation Close
 Identifier   Position   Gene coordinates of cleavage site   Chromosomal coordinates of cleavage site   Pattern   PolyA tail   Accession number   Type 
PA1 20 119969 62538418 yes CR936721 Cdna

More polyadenylation sites ...

Exon skipping Close
 Identifier   Position   Transcript 
ES1 2 CR936721
AF301463
AF310676
ES2 4 NM_022739
AY014180
BC093876
BC111945
AF301463
AF310676
ES3 7 BC051283
Splice site strength Close
 Identifier   Site   Exon   Strength   Alternative   Sequence 
S1 5' (donor) 1 10.07 no CAGgtgagg
S2 5' (donor) 2 10.27 no TCCgtaagt
S3 3' (acceptor) 2 9.5 no tttgttttttttttttacagTAC
S4 5' (donor) 3 3.22 no CCTgtaggt
S5 3' (acceptor) 3 6.63 no tagaaaatcttttttcacagGAC
S6 5' (donor) 4 10.28 no CAGgtaggt
S7 3' (acceptor) 4 10.34 no cctgctctgcttgtctgcagGCA
S8 5' (donor) 5 6.59 no GTTgtgagt
S9 3' (acceptor) 5 9.78 no gcagccgttttgttttttagGTA
S10 5' (donor) 6 9.66 no TAGgtaagt
S11 3' (acceptor) 6 6.07 no tctttgttgacttcaaatagATC
S12 5' (donor) 7 9.14 no CGGgtaagc
S13 3' (acceptor) 7 5.81 no atatttctgtcatttaatagTAA
S14 5' (donor) 8 10.65 no ACGgtaaga
S15 3' (acceptor) 8 4.55 no actcaatatttttatttaagCTG
S16 5' (donor) 9 6.56 no ATGgtatga
S17 3' (acceptor) 9 7.21 no tccttgttaattttcaatagACC
S18 5' (donor) 10 10.77 no CAGgtaaga
S19 3' (acceptor) 10 6.98 no agtgtttattaattttacagAAC
S20 5' (donor) 11 9.72 no AAAgtaagt
S21 3' (acceptor) 11 10.64 no ttttatatttgtttttgcagGGA
S22 5' (donor) 12 8.39 no GAGgtaaat
S23 3' (acceptor) 12 6.87 no acatctatgtttacttctagTCG
S24 5' (donor) 13 9.99 no CAGgtatgg
S25 3' (acceptor) 13 8.5 no ttaaaaattatttttttcagGAA
S26 5' (donor) 14 8.14 no CCGgtatga
S27 3' (acceptor) 14 7.9 no ggtcatatcttgttttctagGGA
S28 5' (donor) 15 5.19 no ACTgtatgt
S29 3' (acceptor) 15 11.39 no tatactgttttcaatttcagGAA
S30 5' (donor) 16 7.82 no CAGgtaaac
S31 3' (acceptor) 16 10.03 no ttttcctctttcctatccagTGA
S32 5' (donor) 17 7.15 no GAGgttagt
S33 3' (acceptor) 17 4.25 no atcctgccgaatgtttacagGCT
S34 5' (donor) 18 8.92 no AAGgtaaca
S35 3' (acceptor) 18 7.75 no actgtgtactattttcacagCTC
S36 5' (donor) 19 8.92 no TTGgtaagg
S37 3' (acceptor) 19 11.56 no cacatttccttcatttgcagGTG
S38 3' (acceptor) 20 6.28 no tttgatttgcttattcacagCTT
Conserved exons Close
 Gene identifier mouse   Position human  Position mouse 
19329 2 2
19329 3 3
19329 5 4
19329 6 5
19329 7 6
19329 8 7
19329 9 8
19329 10 9
19329 11 10
19329 12 11
19329 13 12
19329 14 13
19329 15 14
19329 16 15
19329 17 16
19329 18 17
19329 19 18
Report Close
 Exon   Number of supporting transcripts 
 Transcription initiation & first exon(s) 
1 1
 Transcription termination & last exon(s) 
20 1
 Exon skipping 
2 3
4 6
7 1
 Exon deletions 
1 1
Splicing factors Close
 Splicing factor   Exon array   CLIP data   Exon position 
CELF1 (CUG-BP)
 
DAZAP1
 
ELAVL1 (HuR) Yes Yes
 
ESRP1/2 (ESRP) Yes
 
FUS Yes
 
HNRNPA1 Yes
 
HNRNPA2B1 Yes
 
HNRNPAB
 
HNRNPC Yes
 
HNRNPF/HNRNPH1 Yes Yes
 
HNRNPL Yes
 
HNRNPL_2
 
HNRNPM Yes
 
HNRNPU Yes
 
MBNL
 
NOVA1
 
PTBP1/2 (PTB) Yes Yes
 
QKI
 
RBFOX2 (FOX2) Yes
 
RBM4 Yes
 
SFRS3 (SRP20)
 
SFRS6 (SRP55)
 
SFRS7 (9G8)
 
SRSF1 (SF2ASF)
 
SRSF2 (SC35)
 
SRSF5 (SRP40)
 
TDP43
 
TIA1/TIAL1 Yes
 
TRA2A
 
TRA2B
 
YBX1 (YB1)
 
Expression Close
 Exon position   Tissues   Cell lines   Cancer cell lines 
1 Expression Expression Expression
2 Expression Expression Expression
3 Expression Expression Expression
4 Expression Expression Expression
5 Expression Expression Expression
6 Expression Expression Expression
7 Expression Expression Expression
8 Expression Expression Expression
9 Expression Expression Expression
10 Expression Expression Expression
11 Expression Expression Expression
12 Expression Expression Expression
13 Expression Expression Expression
14 Expression Expression Expression
15 Expression Expression Expression
16 Expression Expression Expression
17 Expression Expression Expression
18 Expression Expression Expression
19 Expression Expression Expression
20 Expression Expression Expression
Exon-Intron Close
 Position   Type   Gene coordinates   Chromosomal coordinates   Length   Sequence   Features 
1 Exon 1 - 440 62657947-62658386 440 sequence download
1 Intron 441 - 55628 62602759-62657946 55188 sequence -
2 Exon 55629 - 55667 62602720-62602758 39 sequence download
2 Intron 55668 - 63778 62594609-62602719 8111 sequence -
3 Exon 63779 - 63887 62594500-62594608 109 sequence download
3 Intron 63888 - 68164 62590223-62594499 4277 sequence -
4 Exon 68165 - 68278 62590109-62590222 114 sequence download
4 Intron 68279 - 68695 62589692-62590108 417 sequence -
5 Exon 68696 - 68829 62589558-62589691 134 sequence download
5 Intron 68830 - 71119 62587268-62589557 2290 sequence -
6 Exon 71120 - 71185 62587202-62587267 66 sequence download
6 Intron 71186 - 76098 62582289-62587201 4913 sequence -
7 Exon 76099 - 76183 62582204-62582288 85 sequence download
7 Intron 76184 - 78724 62579663-62582203 2541 sequence -
8 Exon 78725 - 78808 62579579-62579662 84 sequence download
8 Intron 78809 - 81277 62577110-62579578 2469 sequence -
9 Exon 81278 - 81480 62576907-62577109 203 sequence download
9 Intron 81481 - 83692 62574695-62576906 2212 sequence -
10 Exon 83693 - 83777 62574610-62574694 85 sequence download
10 Intron 83778 - 90312 62568075-62574609 6535 sequence -
11 Exon 90313 - 90471 62567916-62568074 159 sequence download
11 Intron 90472 - 99302 62559085-62567915 8831 sequence -
12 Exon 99303 - 99498 62558889-62559084 196 sequence download
12 Intron 99499 - 100665 62557722-62558888 1167 sequence -
13 Exon 100666 - 100769 62557618-62557721 104 sequence download
13 Intron 100770 - 104546 62553841-62557617 3777 sequence -
14 Exon 104547 - 104661 62553726-62553840 115 sequence download
14 Intron 104662 - 106270 62552117-62553725 1609 sequence -
15 Exon 106271 - 106449 62551938-62552116 179 sequence download
15 Intron 106450 - 107275 62551112-62551937 826 sequence -
16 Exon 107276 - 107413 62550974-62551111 138 sequence download
16 Intron 107414 - 110564 62547823-62550973 3151 sequence -
17 Exon 110565 - 110685 62547702-62547822 121 sequence download
17 Intron 110686 - 114467 62543920-62547701 3782 sequence -
18 Exon 114468 - 114669 62543718-62543919 202 sequence download
18 Intron 114670 - 115930 62542457-62543717 1261 sequence -
19 Exon 115931 - 116006 62542381-62542456 76 sequence download
19 Intron 116007 - 116321 62542066-62542380 315 sequence -
20 Exon 116322 - 119969 62538418-62542065 3648 sequence download
Close  5' untranslated regions 
 UTR 1   UTR 2   UTR 3 
 Supporting GenBank
accession identifers 
NM_022739
AY014180
BC093876
BC111945
CR936721
BC051283
 Length  388 846 800
 Number of ATGs in frame  0 1 3
 Total number of ATGs  1 13 13
 Number of GTGs in frame  0 4 3
 Total number of GTGs  5 18 19
 Number of CTGs in frame  5 4 2
 Total number of CTGs  6 13 15
 Number of micro ORFs in frame  0 1 1
 Total number of micro ORFs  1 5 5
 GC percentage  80 48 49
 Number of pyrimidine tracks  1 2 2
Close 3' untranslated regions 
 UTR 1 
 Supporting GenBank
accession identifers 
CR936721
NM_022739
BC051283
BC009527
AY014180
BC093876
BC111945
AF301463
 Length  3548
 Number of ATGs in frame  27
 Total number of ATGs  71
 Number of GTGs in frame  20
 Total number of GTGs  52
 Number of CTGs in frame  17
 Total number of CTGs  52
 GC percentage  36
 Number of pyrimidine tracks  22
miRNAs Close
 Identifier    Name    Gene coordinates   Chromosomal coordinates   Prediction algorithm 
Group 1
M1 hsa-miR-296-3p 116441 - 116464 62541923 - 62541946 miranda
M2 hsa-miR-128 116551 - 116571 62541816 - 62541836 miranda
M3 hsa-miR-128 116563 - 116571 62541816 - 62541824 targetscan
M4 hsa-miR-27a 116564 - 116571 62541816 - 62541823 pita
M5 hsa-miR-27b 116564 - 116571 62541816 - 62541823 pita
M6 hsa-miR-128 116564 - 116570 62541817 - 62541823 pita
M7 hsa-miR-142-5p 116616 - 116623 62541764 - 62541771 pictar
M8 hsa-miR-330 116622 - 116629 62541758 - 62541765 pictar
M9 hsa-miR-330-3p 116622 - 116628 62541759 - 62541765 pita
M10 hsa-miR-646 116644 - 116651 62541736 - 62541743 pita
M11 hsa-miR-195 116645 - 116652 62541735 - 62541742 pictar
M12 hsa-miR-16 116645 - 116652 62541735 - 62541742 targetscan
M13 hsa-miR-16 116645 - 116652 62541735 - 62541742 pictar
M14 hsa-miR-195 116645 - 116652 62541735 - 62541742 targetscan
M15 hsa-miR-15b 116645 - 116652 62541735 - 62541742 pictar
M16 hsa-miR-424 116645 - 116652 62541735 - 62541742 targetscan
M17 hsa-miR-15a 116645 - 116652 62541735 - 62541742 pictar
M18 hsa-miR-503 116645 - 116652 62541735 - 62541742 targetscan
M19 hsa-miR-497 116645 - 116652 62541735 - 62541742 targetscan
M20 hsa-miR-15a 116645 - 116652 62541735 - 62541742 targetscan
M21 hsa-miR-15b 116645 - 116652 62541735 - 62541742 targetscan
M22 hsa-miR-497 116669 - 116690 62541697 - 62541718 miranda
M23 hsa-miR-1179 116678 - 116685 62541702 - 62541709 pita
M24 hsa-miR-200c 116698 - 116720 62541667 - 62541689 miranda
M25 hsa-miR-429 116699 - 116720 62541667 - 62541688 miranda
M26 hsa-miR-200b 116699 - 116720 62541667 - 62541688 miranda
M27 hsa-miR-875-3p 116699 - 116705 62541682 - 62541688 pita
M28 hsa-miR-1299 116700 - 116706 62541681 - 62541687 pita
M29 hsa-miR-200b 116712 - 116719 62541668 - 62541675 targetscan
M30 hsa-miR-200c 116712 - 116719 62541668 - 62541675 targetscan
M31 hsa-miR-429 116712 - 116719 62541668 - 62541675 targetscan
M32 hsa-miR-200c 116712 - 116719 62541668 - 62541675 pictar
M33 hsa-miR-200b 116712 - 116719 62541668 - 62541675 pita
M34 hsa-miR-200b 116712 - 116719 62541668 - 62541675 pictar
M35 hsa-miR-200c 116712 - 116719 62541668 - 62541675 pita
M36 hsa-miR-429 116713 - 116719 62541668 - 62541674 pita
M37 hsa-miR-146a 116770 - 116793 62541594 - 62541617 miranda
M38 hsa-miR-382 116803 - 116809 62541578 - 62541584 pita
M39 hsa-miR-203 116812 - 116836 62541551 - 62541575 miranda
M40 hsa-miR-203 116828 - 116835 62541552 - 62541559 pita
M41 hsa-miR-28-5p 116842 - 116869 62541518 - 62541545 miranda
M42 hsa-miR-708 116846 - 116869 62541518 - 62541541 miranda
M43 hsa-miR-708 116862 - 116868 62541519 - 62541525 pita
M44 hsa-miR-28-5p 116862 - 116868 62541519 - 62541525 pita
M45 hsa-miR-1276 116875 - 116881 62541506 - 62541512 pita
M46 hsa-miR-524-5p 116878 - 116884 62541503 - 62541509 pita
M47 hsa-miR-520d-5p 116878 - 116884 62541503 - 62541509 pita
M48 hsa-miR-590-3p 116880 - 116900 62541487 - 62541507 miranda
M49 hsa-miR-590-3p 116892 - 116899 62541488 - 62541495 pita
M50 hsa-miR-548m 116914 - 116920 62541467 - 62541473 pita
M51 hsa-miR-524-5p 116916 - 116923 62541464 - 62541471 pita
M52 hsa-miR-520d-5p 116916 - 116923 62541464 - 62541471 pita
M53 hsa-miR-135a 116944 - 116965 62541422 - 62541443 miranda
M54 hsa-miR-135b 116945 - 116965 62541422 - 62541442 miranda
M55 hsa-miR-135a 116958 - 116964 62541423 - 62541429 pita
M56 hsa-miR-135b 116958 - 116964 62541423 - 62541429 pita
M57 hsa-miR-216b 116973 - 116998 62541389 - 62541414 miranda
M58 hsa-miR-155 116979 - 116999 62541388 - 62541408 miranda
M59 hsa-miR-155 116992 - 116998 62541389 - 62541395 pita
M60 hsa-miR-494 116998 - 117019 62541368 - 62541389 miranda
M61 hsa-miR-494 117011 - 117018 62541369 - 62541376 pita
M62 hsa-miR-32 117120 - 117148 62541239 - 62541267 miranda
M63 hsa-miR-1225-3p 117159 - 117166 62541221 - 62541228 pita
M64 hsa-miR-137 117204 - 117228 62541159 - 62541183 miranda
M65 hsa-miR-577 117210 - 117217 62541170 - 62541177 pita
M66 hsa-miR-559 117245 - 117252 62541135 - 62541142 pita
M67 hsa-miR-548d-5p 117246 - 117252 62541135 - 62541141 pita
M68 hsa-miR-548h 117246 - 117252 62541135 - 62541141 pita
M69 hsa-miR-548i 117246 - 117252 62541135 - 62541141 pita
M70 hsa-miR-548a-5p 117246 - 117252 62541135 - 62541141 pita
M71 hsa-miR-548j 117246 - 117252 62541135 - 62541141 pita
M72 hsa-miR-548b-5p 117246 - 117252 62541135 - 62541141 pita
M73 hsa-miR-548c-5p 117246 - 117252 62541135 - 62541141 pita
M74 hsa-miR-548n 117246 - 117253 62541134 - 62541141 pita
M75 hsa-miR-605 117303 - 117310 62541077 - 62541084 pita
M76 hsa-miR-9 117348 - 117369 62541018 - 62541039 miranda
M77 hsa-miR-9 117361 - 117368 62541019 - 62541026 pita
M78 hsa-miR-33a 117362 - 117384 62541003 - 62541025 miranda
M79 hsa-miR-338-5p 117392 - 117398 62540989 - 62540995 pita
M80 hsa-miR-569 117422 - 117428 62540959 - 62540965 pita
M81 hsa-miR-651 117435 - 117441 62540946 - 62540952 pita
M82 hsa-miR-590-5p 117499 - 117520 62540867 - 62540888 miranda
M83 hsa-miR-21 117501 - 117520 62540867 - 62540886 miranda
M84 hsa-miR-26a 117589 - 117613 62540774 - 62540798 miranda
M85 hsa-miR-26b 117590 - 117613 62540774 - 62540797 miranda
M86 hsa-miR-1297 117596 - 117613 62540774 - 62540791 miranda
Protein features Close
 Category   Feature identifier   Feature name   Exons   Start on gene   End on gene 
Catalytic EXONT:002303 HECT 12,13,14,15,16,17,18,19,20 99421 116418
Binding EXONT:004898 Identical protein binding 1,2,3,5,6,7 416 76118
Binding EXONT:001885 Protein binding 1,2,3,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20 416 116418
Binding EXONT:001886 C2 domain 1,2,3,4,5,6,7 419 76109
Binding EXONT:002681 WW domain 7,8,9 76155 81284
Binding EXONT:002681 WW domain 9,10,11 81441 90313
Binding EXONT:002681 WW domain 11 90326 90448
Binding EXONT:004898 Identical protein binding 12,13,14,15,16,17,18,19,20 99382 116418
Localization EXONT:000064 Nuclear_localization_signal 14 104569 104589
Localization EXONT:000065 Endosomal_localization_signal 14 104581 104592
Localization EXONT:000066 Lysosomal_localization_signal 14 104581 104592
Localization EXONT:000067 Nuclear_export_signal 16 107283 107321
Localization EXONT:000064 Nuclear_localization_signal 20 116329 116349
Structure EXONT:000074 Intrinsically_unstructured_polypeptide_region 1 389 421
Structure EXONT:000051 Beta_strand 1,2 422 55645
Structure EXONT:000051 Beta_strand 3 63790 63810
Structure EXONT:000022 Polypeptide_turn_motif 3 63811 63819
Structure EXONT:000051 Beta_strand 3 63829 63837
Structure EXONT:000051 Beta_strand 3,5 63865 68702
Structure EXONT:000051 Beta_strand 5 68718 68738
Structure EXONT:000037 Peptide_helix 5 68739 68756
Structure EXONT:000051 Beta_strand 5 68772 68792
Structure EXONT:000037 Peptide_helix 5 68796 68825
Structure EXONT:000051 Beta_strand 6 71122 71130
Structure EXONT:000051 Beta_strand 6,7 71176 76112
Structure EXONT:000074 Intrinsically_unstructured_polypeptide_region 8,9 78789 81338
Structure EXONT:000074 Intrinsically_unstructured_polypeptide_region 9,10 81345 83703
Structure EXONT:000051 Beta_strand 9,10 81480 83706
Structure EXONT:000022 Polypeptide_turn_motif 10 83707 83715
Structure EXONT:000051 Beta_strand 10 83716 83733
Structure EXONT:000022 Polypeptide_turn_motif 10 83734 83745
Structure EXONT:000051 Beta_strand 10 83746 83760
Structure EXONT:000051 Beta_strand 10 83764 83772
Structure EXONT:000051 Beta_strand 10,11 83776 90319
Structure EXONT:000037 Peptide_helix 11 90332 90340
Structure EXONT:000051 Beta_strand 11 90356 90376
Structure EXONT:000051 Beta_strand 11 90380 90388
Structure EXONT:000051 Beta_strand 11 90392 90406
Structure EXONT:000022 Polypeptide_turn_motif 11 90407 90418
Structure EXONT:000051 Beta_strand 11 90419 90433
Structure EXONT:000022 Polypeptide_turn_motif 11 90437 90445
Structure EXONT:000037 Peptide_helix 12 99400 99444
Structure EXONT:000051 Beta_strand 12 99460 99477
Structure EXONT:000037 Peptide_helix 12,13 99490 100686
Structure EXONT:000037 Peptide_helix 13 100696 100710
Structure EXONT:000051 Beta_strand 13 100711 100731
Structure EXONT:000037 Peptide_helix 13,14 100753 104577
Structure EXONT:000037 Peptide_helix 14 104584 104592
Structure EXONT:000051 Beta_strand 14 104593 104610
Structure EXONT:000051 Beta_strand 14 104617 104637
Structure EXONT:000037 Peptide_helix 14 104647 104655
Structure EXONT:000037 Peptide_helix 15 106274 106324
Structure EXONT:000037 Peptide_helix 15 106355 106375
Structure EXONT:000037 Peptide_helix 15 106403 106414
Structure EXONT:000037 Peptide_helix 15,16 106418 107279
Structure EXONT:000022 Polypeptide_turn_motif 16 107289 107297
Structure EXONT:000051 Beta_strand 16 107310 107330
Structure EXONT:000051 Beta_strand 16 107337 107360
Structure EXONT:000022 Polypeptide_turn_motif 16 107385 107396
Structure EXONT:000037 Peptide_helix 16,17 107397 110586
Structure EXONT:000022 Polypeptide_turn_motif 17 110587 110598
Structure EXONT:000037 Peptide_helix 17 110599 110640
Structure EXONT:000037 Peptide_helix 17 110647 110658
Structure EXONT:000037 Peptide_helix 17,18 110671 114479
Structure EXONT:000051 Beta_strand 18 114483 114491
Structure EXONT:000037 Peptide_helix 18 114498 114515
Structure EXONT:000051 Beta_strand 18 114519 114536
Structure EXONT:000037 Peptide_helix 18 114549 114584
Structure EXONT:000037 Peptide_helix 18 114591 114626
Structure EXONT:000051 Beta_strand 18 114633 114641
Structure EXONT:000037 Peptide_helix 18 114654 114662
Structure EXONT:000051 Beta_strand 19 115951 115965
Structure EXONT:000051 Beta_strand 19 115993 116001
Structure EXONT:000037 Peptide_helix 19,20 116002 116325
Structure EXONT:000051 Beta_strand 20 116329 116340
Structure EXONT:000037 Peptide_helix 20 116356 116391
PTM EXONT:000162 O-phospho-L-threonine 8 78741 78743
PTM EXONT:000161 O-phospho-L-serine 8 78747 78749
PTM EXONT:000161 O-phospho-L-serine 9 81315 81317
PTM EXONT:000161 O-phospho-L-serine 13 100669 100671
PTM EXONT:000164 O4'-phospho-L-tyrosine 13 100672 100674
PTM EXONT:000164 O4'-phospho-L-tyrosine 13 100753 100755
PTM EXONT:000164 O4'-phospho-L-tyrosine 15 106334 106336
Gene SMURF2
Gene SMURF2 Gene SMURF2
Gene SMURF2 Gene SMURF2
Gene SMURF2 Gene SMURF2
Gene SMURF2 Gene SMURF2
Gene SMURF2 Gene SMURF2
Gene SMURF2 Gene SMURF2
Gene SMURF2 Gene SMURF2
Gene SMURF2 Gene SMURF2

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Exon 1Exon 2Exon 3Exon 4Exon 5Exon 6Exon 7Exon 8Exon 9Exon 10Exon 11Exon 12Exon 13Exon 14Exon 15Exon 16Exon 17Exon 18Exon 19Exon 1Exon 2Exon 3Exon 4Exon 5Exon 6Exon 7Exon 8Exon 9Exon 10Exon 11Exon 12Exon 13Exon 14Exon 15Exon 16Exon 17Exon 18Exon 19Exon 20Extended region